Environments：
Server：Ubuntu 22.04.3 LTS
Nginx：1.18.0
PHP：8.1.2
MySQL：8.0.40

Step 1：创建wordpress数据库和对应权限的数据库用户

CREATE DATABASE wordpress CHARACTER SET utf8mb4 COLLATE utf8mb4_general_ci;
CREATE USER 'wordpress'@'localhost' IDENTIFIED BY 'your_password_here';
GRANT ALL PRIVILEGES ON wordpress.* TO 'wordpress'@'localhost';
flush privileges;

Step 2：下载安装WordPress

mkdir -p /var/www/html/runs.wang
cd /tmp
wget https://wordpress.org/latest.tar.gz
tar -xvzf latest.tar.gz
mv /tmp/wordpress/* /var/www/html/runs.wang/
chown -R www-data: /var/www/html/runs.wang

Step 3：设置Nginx

cd /etc/nginx/sites-available
cp default default.back
vim default

server {

root /var/www/html/runs.wang;

# Add index.php to the list if you are using PHP
index index.php index.html index.htm index.nginx-debian.html;
server_name runs.wang; # managed by Certbot


location / {
        # First attempt to serve request as file, then
        # as directory, then fall back to displaying a 404.
        try_files $uri $uri/ /index.php?$args;
}


location = /favicon.ico {
        log_not_found off;
        access_log off;
}
location ~* \.(js|css|png|jpg|jpeg|gif|ico)$ {
expires max;
log_not_found off;
}
location = /robots.txt {
allow all;
log_not_found off;
access_log off;
}

# pass PHP scripts to FastCGI server
#
location ~ \.php$ {
        include snippets/fastcgi-php.conf;
#
#       # With php-fpm (or other unix sockets):
        fastcgi_pass unix:/var/run/php/php8.1-fpm.sock;
        fastcgi_param SCRIPT_FILENAME $document_root$fastcgi_script_name;
        include fastcgi_params;
#       # With php-cgi (or other tcp sockets):
#       fastcgi_pass 127.0.0.1:9000;
}

# deny access to .htaccess files, if Apache's document root
# concurs with nginx's one
#
#location ~ /\.ht {
#       deny all;
#}

listen [::]:443 ssl ipv6only=on; # managed by Certbot
listen 443 ssl; # managed by Certbot
ssl_certificate /etc/letsencrypt/live/runs.wang/fullchain.pem; # managed by Certbot
ssl_certificate_key /etc/letsencrypt/live/runs.wang/privkey.pem; # managed by Certbot
include /etc/letsencrypt/options-ssl-nginx.conf; # managed by Certbot
ssl_dhparam /etc/letsencrypt/ssl-dhparams.pem; # managed by Certbot
}


server {
if ($host = runs.wang) {
return 301 https://$host$request_uri;
} # managed by Certbot

listen 80 ;
listen [::]:80 ;
server_name runs.wang;
return 404; # managed by Certbot
}

Step 4：重启Nginx

nginx -t
systemctl restart nginx

Step 5：打开浏览器输入地址runs.wang根据之前创建的数据库信息初始化页面即可

References：
《WordPress Nginx: Everything You Need to Know About Installing WordPress on Ubuntu》
《How to install and configure WordPress with NGINX》